Polysporin Vs. Neosporin: What's The Difference?

While Neosporin and Polysporin are similar, there's at least one significant difference, according to Drugs.com. Both ointments contain bacitracin zinc and polymyxin B sulfate. However, only Neosporin contains neomycin. According to Iodine, Polysporin is easy to use, but it may cause a skin rash in some people and can't be used for significant skin infections, animal bites, deep wounds, or serious burns. It comes in a powder or an ointment. As for Neosporin, it is not for use in deep cuts or injuries, but you can use it to help treat pain, itching, and scars in specific formulations. It comes in several forms, including ointment, cream, foam, and spray.

For minor cuts, you could likely use either Neosporin or Polysporin with the latter having an edge if you need a formulation for scars, itching, or pain. However, if it's something more serious, you might need to talk to your doctor about more appropriate treatment options.