Katherine Heigl's Least Favorite Grey's Anatomy Scene Of All Time

If you've watched "Grey's Anatomy," you'll definitely remember the storyline between Katherine Heigl's character Izzie and Jeffrey Dean Morgan's character Denny Duquette. Denny dies during the season 2 finale after a lot of drama, but he comes back as a ghost/hallucination in season 5 that only Izzie can see. Seeing Denny turns out to be one of the symptoms of her cancer, but before she discovers the reason for the hallucination, she gets intimate with him. Kind of a lot. But all the while, Izzie is dating non-ghost Alex Karev, played by Justin Chambers. During a hook-up between Izzie and Alex in the hospital's on-call room, Denny is there too.

Heigl brought up the awkwardness of the scene as she spoke with Ellen Pompeo, who plays Meredith Grey, on "Actors on Actors." Heigl spoke about how stressful and weird it would be to watch certain scenes from "Grey's Anatomy" with her daughters — Heigl has two daughters and a son — noting that it'd be hard to explain that scene between Izzie, Alex, and Denny.

Before the storyline with Denny the ghost and cancer, Heigl won the Emmy for Outstanding Supporting Actress in a Drama Series for portraying Izzie Stevens in season 3. She later told Entertainment Weekly that the win was "the highlight of my career." But by the next season, Heigl was making Emmy news for a much different reason.